The study shows that dental thread can effectively release vaccines through the gums

The dental thread could possibly do much more than improving oral hygiene.

A new study led by Texas Tech University and the University of North Carolina suggests that the thin filament could possibly serve as a vaccine mechanism.

In animal models, researchers have shown that dental wire can effectively release vaccines through the fabric between teeth and gums, according to a press release.

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In the study, the technique of dental silk sparked the production of antibodies in “mucous surfaces”, such as the mucosa of the nose and lungs, said the release.

The results were published in the journal Nature Biomedical Engineering.

A new study by Texas Tech University and the University of North Carolina suggests that the dental thread could possibly serve as a vaccine mechanism. (istock)

“The mucous surfaces are important because they are a source of entry for pathogens, such as the flu and the covid,” said co-author Harvdernder Singh Gill, professor of chemical and biomolecular genius at North Carolina State University, in the press release.

With the traditional vaccine injection method, antibodies are mainly produced in the blood circulation, he noted.

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“But we know that when a vaccine is given via the mucous surface, antibodies are stimulated not only in the blood circulation, but also on mucous surfaces,” said Gill.

“This improves the body’s ability to prevent infection, as there is an additional line of defense of antibodies before a pathogen enters the body.”

Researchers have shown that dental thread can effectively release vaccines through the fabric between teeth and gums. (istock)

The vaccine between “junctional epithelium”, which is a thin layer of fabric in the deep pocket between the tooth and gum.

This fabric does not have the same barrier as the other tissue liners, which means that it can release immune cells in the body.

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In the study, the researchers added a vaccine against peptide influenza to unwavering dental silk before the dental silk of the teeth of the laboratory mice, according to the press release.

Then, they compared the effectiveness of the dental silk vaccine to techniques that have delivered it to the nasal or orally.

“It would be easy to administer, and this responds to the concerns that many people have to be vaccinated with needles.”

“We have found that the application of the vaccine via the junctional epithelium produces a much higher antibody response on mucous surfaces that the current gold stallion for vaccination via the oral cavity, which implies placing the vaccine under the language,” said the first author Rohan Ingrole, a doctorate. Student at Texas Tech University.

“The dental silk technique also provides comparable protection against the flu virus compared to the vaccine given via the nasal epithelium.”

With the traditional vaccine injection method, antibodies are mainly produced in the bloodstream, the researchers noted. (istock)

In addition to the flu, the test was repeated for three other types of vaccines: proteins, inactivated viruses and mRNA.

For all types, the technique of dental silk has produced “robust antibody responses in blood circulation and through mucous surfaces,” said release.

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Then, the research team aims to test the efficiency of the delivery of vaccines to the epithelial junction in humans thanks to the use of wire choice, which are easier to hold.

“It would be easy to administer, and this responds to the concerns that many people have to be vaccinated with needles,” said Gill. “And we believe that this technique should be comparable as a price for other techniques of vaccine delivery.”

For the four types of vaccines tested, the dental silk technique produced “responses from robust antibodies in the bloodstream and through mucous surfaces,” said researchers. (istock)

Hua Wang, assistant professor of science and material engineering at the Graining College of Engineering at the University of Illinois, was not involved in the study but shared his reaction to the results.

“This study presents a promising wire-based vaccination method which can avoid needle injection or any potentially painful procedure,” he told Fox News Digital.

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“The authors have shown that the components of the vaccine in the coating of dental silk can penetrate the junctional epithelium into the gingival sulcus and reach the underlying tissues, leading to systemic responses of antibodies.”

The dental-based vaccination method could help improve patient compliance if it involves the complete evaluation process, he noted.

Future limitations and research

There are certain limits and disadvantages associated with vaccines based on dental silk, have recognized the researchers.

Babies and toddlers who do not yet have teeth would not be candidates for technique, for example.

“In addition, we would need to know more about how this approach would work for people with a gum disease or other oral infections,” added Gill.

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Wang has agreed that many questions remain to be answered about this experimental vaccination method.

“In addition to the unclear impact of the infection of gum tissue on vaccination, the local and systemic side effects of this vaccination method remain to be understood,” he told Fox News Digital.

“This study has a promising wire vaccination method that can avoid needle injection or any potentially painful procedure,” said an expert. (istock)

“For example, vaccination in the gingival tissue can trigger local inflammation which ends up inducing unwanted side effects.”

It is not yet clear on which exact path the vaccine components follow during the authorization of the dental site to the tissues or how the immune responses are generated, Wang noted.

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“Finally, from the translation point of view, the effectiveness of wire -based vaccines should be comparable to conventional needle vaccines.”

The study was funded by the National Institutes of Health (NIH) and by the Whitacre Doed Chair Funds in Texas Tech University.