Cardinals’ Kyler Murray out for Week 6 game vs. Colts
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Arizona Cardinals quarterback Kyler Murray has been ruled out of Sunday’s game against the Indianapolis Colts with a foot injury.
Murray did not practice Wednesday or Thursday. He was limited in practice Friday. And, about an hour before kickoff against the Colts, the team turned it off. Veteran quarterback Jacoby Brissett is expected to start in his place.
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Arizona Cardinals quarterback Kyler Murray (1) looks to throw a pass during the first half of an NFL football game against the Tennessee Titans, Sunday, Oct. 5, 2025, in Glendale, Arizona. (AP Photo/Rick Scuteri)
The star quarterback suffered a midfoot sprain. THE NFL Network reported that Murray may have to sit for more than just the Week 6 game against Indianapolis. He missed two games during the team’s disastrous loss to the Tennessee Titans last week.
Murray, who is in the seventh year of his career, has 962 passing yards and six touchdowns for the Cardinals. He also has three interceptions this year.
Arizona Cardinals quarterback Kyler Murray (1) runs the ball against Tennessee Titans safety Amani Hooker, right, during the second half of an NFL football game, Sunday, Oct. 5, 2025, in Glendale, Arizona. (AP Photo/Ross D. Franklin)
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He was Arizona’s No. 1 overall pick in the 2019 draft. He was named the 2019 Offensive Rookie of the Year and guided the team to the playoffs during the 2021 season. He signed a five-year contract extension worth $230.5 million in 2022.
Arizona will enter the Week 6 game with a 2-3 record. The team is 23rd in points scored and 26th in yards gained. The Cardinals finished 8-9 last season.
Arizona Cardinals quarterback Kyler Murray (1) and wide receiver Marvin Harrison Jr. (18) leave the field after the team’s loss in an NFL football game against the Tennessee Titans, Sunday, Oct. 5, 2025, in Glendale, Arizona. (AP Photo/Ross D. Franklin)
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Kedon Slovis is listed as the third quarterback on the Cardinals roster.
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